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1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
This compound is an experimental small molecule belonging to the class of aminopyrimidines and derivatives. It is identified by its IUPAC name and has a molecular formula of C18H17F3N10O2S with a molecular weight of approximately 494.45 Da[1][5]. The compound acts as an inhibitor of serine/threonine-protein kinase PLK1 (Polo-like kinase 1), with an IC50 value of approximately 720 nM[1]. PLK1 is involved in cell cycle regulation and mitosis; inhibition can lead to disruption of cell division and may have antitumor effects. There are no approved indications or marketed products for this molecule; it remains at the experimental stage.
- Other names
- 1-[5-Methyl-2-(trifluoromethyl)-3-furyl]-3-[5-(2-{[6-(1H-1,2,4-triazol-3/5/7/9/11/13/15-yloxy)pyrimidinyl]amino}ethyl)-1,3-thiazol-2(3H)-ylidene]ureaN-[5-methyl-2-(trifluoromethyl)-3-furanyl]-N′-[5-[2-[[6-(1H‑1,2,4‑triazol‑5‑ylamino)‑4-pyrimidinyl]amino]ethyl]-thiazolyl]-Urea
02
Targets
PLK1 (Polo like kinase 1)
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